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Funded 3 year PhD position – The studentship covers home/EU tuition fees (£4,260 in 2018/19) plus a generous stipend equivalent to the full UK Research Innovation rate of £14,777. – Sheffield Hallam University
Extracellular Vesicles: small packages with a big role in bowel cancer metastasis
Background: Patients with metastatic colorectal cancer (CRC) have poor survival rates, reflecting the difficulty in treating advanced disease. The events that lead to CRC metastases establishing are poorly understood; recently it has been proposed that extracellular vesicles (EVs) condition metastatic sites through organ-specific uptake. This project will determine the molecular processes driving metastasis and the role of EVs, aiming to develop new treatment approaches for advanced disease and to support monitoring and diagnosis of metastatic CRC.
Aims: 1) Develop a detailed understanding of CRC metastasis. 2) Develop an understanding of how/why CRC metastasises to particular sites. 3) Determine how EVs contribute to CRC metastasis.
Methods: Organotypic models of metastatic sites will be developed, which will be analysed histologically, biomechanically, and proteomically to develop signatures linked to metastatic progression. Models will also be conditioned using EVs from CRC cells, and the impact of this conditioning on invasion and metastatic signatures will be assessed. Micro-RNA profiles of EVs will be characterised and linked to their effects. These effects will then be validated in CRC tissues.
Outcomes: We will develop molecular signatures of metastatic progression in vitro, linked to histological and biomechanical features of tissue remodelling. Identifying key pathways linked to metastasis and important site-specific features will provide a basis for treatment approaches. We will use molecular manipulation to assess the putative role of a key mediators of invasion identified in this profiling, including the important enzyme TG2. We will then link EV miRNA profiles to their effects, identifying potential biomarkers of metastasis.
The project will benefit from extensive culture and 3D modelling facilities in the Biomolecular Sciences Research Centre, and MALDI-imaging technology in the Centre for Mass Spectrometry Imaging at SHU. Dr Peake and Professor Le Maitre are established researchers with vast experience of developing in vitro models of disease and will provide full training. Dr Cole is an expert in MALDI imaging and complementary analytical techniques which will be used to develop molecular signatures in the model. The student will also benefit from working with established collaborators at the University of Sheffield and the University of Southampton, who will provide support for extracellular vesicle isolation and analysis, and clinical samples for translational impact.
Successful applicants will possess all of the attributes listed below.
• A first class or upper second class honours degree in cancer biology, molecular biology, cell biology, protein biology or a related discipline or a distinction at MSc. Experience working in a research laboratory for at least one year is desirable.
• Excellent communication skills in English (speaking and writing).
• Ability to work independently and within a team
• Highly motivated with a commitment to conduct high quality research
• Excellent time management skills
This PhD is primarily funded by Bowel & Cancer Research, with additional support from the SHU “creating knowledge” collaborative PhD scheme.
An application form can be downloaded at the following URL:
For informal enquiries about the project please contact Dr Nick Peake: firstname.lastname@example.org
• Deadline for applications 31st March, 2019
• Interviews will be held in April
• Studentship to begin in May, or in exceptional circumstances, October.
Postdoctoral Research Associate – Salary: £32,236.00 – £39,609.00 (Grade 7) – University of Cambridge
Limit of Tenure: From 1st January 2019 (or as soon as possible thereafter) for 24 months
Applications are invited for this postdoctoral position, as part of a project funded by the Petplan Charitable Trust, which will aim to identify novel biomarkers of bladder cancer (urothelial carcinoma) in dogs. Early diagnosis of bladder cancer in dogs is currently hampered by the late onset of symptoms and a lack of reliable non-invasive
diagnostic tests, therefore this project will investigate if miRNAs within urinary extracellular vesicles (EVs) can be used as non-invasive biomarkers for urothelial carcinoma in dogs.
The applicant will work alongside Dr Tim Williams and Professor Fiona Karet, both of which have a proven track record in EV research, and Dr Andrew Grant and Dr Lajos Kalmar, who have extensive experience in transcriptome analysis, including bioinformatics. The main focus of the research led by Dr Williams and Professor Karet, is to study the biology of EVs and investigate their utility as a source of biomarkers of renal and urinary tract diseases in humans and mammals.
Applicants should have a PhD, in Molecular Biology or a related discipline, and ideally have either experience in quantitative molecular biology and/or extracellular vesicle research. Expertise in bioinformatics is also desirable but not essential. The candidate must value teamwork and collaboration, have good administrative and interpersonal skills, and high computer literacy especially in relation to the analysis of DNA sequences and the use of bioinformatics software.
For further information see: http://www.jobs.cam.ac.uk/job/
The Oxford Interdisciplinary Bioscience Doctoral Training Partnership
Also try: www.findapostdoc.com, or https://academicpositions.com in the EU.
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