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Post-Doctoral Research Fellow Position – Trinity College Dublin.
Post title: Research Fellow (Post-Doctoral)
Post status: 4 years, specific purpose Contract, Full-time, commencing immediately or any time prior to 1st February 2020
Research Group / Department / School: O’Driscoll Group School of Pharmacy & Pharmaceutical Sciences and Trinity Biomedical Sciences Institute
Location: Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland
Reports to: Prof. Lorraine O’Driscoll
Salary: Appointment will be made on the IUA Post-Doctoral Researcher Level 2 Point 1, with annual increment in line with Government Pay Policy and funding for additional training and conference travel
Hours of Work: 37.5 hours per week
Closing Date: 12 Noon (Irish Standard Time), 28th November 2019
Post Summary: Our research group (the O’Driscoll group) at Trinity College Dublin has extensive experience in research of exosomes and other extracellular vesicles (collectively termed EVs). EVs are emerging as important players in cell-to-cell communication under physiological and pathological circumstances. Some studies have suggested significantly more EVs in cancer patients’ blood compared to healthy controls; other have not. We hypothesis that this conflict in observation may be due to EVs’ heterogenous nature. Here we will more comprehensively investigate this. In vitro and in vivo studies across several solid tumour types implicate EVs released from cancer cells as causally involved in invasion, angiogenesis, metastasis and drug-resistance. Previous attempts to block EV release, and so these consequences, have been hampered by the approaches used also affecting EV release from normal cells that may be important for physiological events. However, we have now established that the microenvironment of the tumour substantially contributes to EV release. This programme will thus investigate this, in efforts to prevent metastasis and drug-resistance. But not all EVs are bad! We have also successfully isolated EVs from normal mesenchymal stem cells (MSCs) with potential as drug/miRNA delivery vehicles. This will be further explored.
Standard Duties and Responsibilities of the Post
▪ Conduct a specified programme of research under the direction and mentorship of Prof. O’Driscoll
▪ Deliver research outputs and provide input into reports as required for the project management schedule
▪ Assist in identifying and developing future research and funding initiatives
▪ Engage in the dissemination of the results of the research in which s/he is engaged, with the support of and under the supervision of Prof. O’Driscoll
Further Information for Applicants
URL Link to Area: www.tcd.ie
URL to Group: http://pharmacy.tcd.ie/research/
The Horizon 2020 MSCA European Training Network proEVLifeCycle is recruiting 10 early stage researchers for the PhD research projects available in its research training programme.
You will jointly clarify the lifecycle of extracellular vesicles and identify novel biomarkers and therapy targets for prostate cancer using state-of-the-art model systems, imaging and profiling tools, and systems biology.
The lifecycle of extracellular vesicles (EVs) is poorly understood and their potential as non-invasive biomarkers and therapy targets is a growing area of interest. This research can perfectly be integrated with the high need for novel biomarkers and therapy targets for prostate cancer. Any relief in the burden of this disease will have major impact on the huge socio-economic problems for patients, families, caregivers and society. In proEVLifeCycle, we aim to unravel the mysteries of EV biogenesis, homing and uptake to explain how EVs operate in disease processes, their heterogeneity, their molecular complexity, the biological functions they drive, their local and systemic dissemination and how these may be manipulated.
Our international consortium is composed of 8 academic institutions and 2 companies based in Austria, Finland, France, Spain, The Netherlands and United Kingdom that offer you excellent and innovative scientific training through research towards a PhD degree and extensive opportunities for mobility and patient-facing experiences, with the support of 11 partner organisations.
Interested to learn more about our vacancies, consortium and programme? Please check the proEVLifeCycle website www.proevlifecycle.eu. Applications should be submitted through our website.
BBSRC Midlands Integrative Biosciences Training Partnership 2020 – Extracellular Vesicles
The proposed work will build on a collective weight of evidence, both from this and other laboratories that suggests that the proteomic signature of an EV determines its organ destination. Examining this experimentally requires the use of high coverage proteomic analyses provided via tandem mass spectrometry. Specifically, the laboratory has developed a ‘pulse chase’ technique whereby tissue specific EV localisation can be tracked using stable isotope labelling of mice. This approach is especially powerful, when combined with targeted analyses of circulating EVs via modern platforms offering phenotype analysis of EV subtypes via a combination of microfluidics, immuno-detection and interferometric imaging. Once specific proteins are identified that mediate tropism to certain tissues, antibodies against these proteins can be used via this system to specifically isolate these EVs and phenotype their cargo in humans.
1) Examine tissue specific uptake of EVs following exercise
2) Validate the protein signature in EVs that mediate tissue specific tropism
3) Identify/validate protein cargo to infer a biological role of this EV delivery in humans.
4) Identify a tissue source of these EVs
Methods used will focus primarily on sample preparation, data acquisition and data analysis associated with quantitative proteomics, with training provided by Dr Martin Whitham (Sport, Exercise and Rehabilitation Sciences). This approach will be supplemented by targeted EV analyses with training and support provided by Dr Paul Harrison (Institute of Inflammation and Ageing).
The Oxford Interdisciplinary Bioscience Doctoral Training Partnership
Also try: www.findapostdoc.com, or https://academicpositions.com in the EU.
Those of you interested in the USA should check out: https://www.exosome-rna.com/tag/postdoc/