Available Positions

If you have any positions, and you’re a member, contact us by email (web@ukev.org.uk) to advertise them below:

Lecturer/Senior Lecturer/Reader in Biosciences – Aston University – 30th May 2022 closing

Full time – Grade 8, 9 or 10 – £36,382 to £60,022 per annum

The School of Biosciences is seeking to make up to four appointments at Lecturer/Senior Lecturer/Reader level to enhance the research, impact and teaching profile of the School.  Led by an ambitious research and development strategy, we are seeking to build upon and develop our established research strengths.

We are particularly interested in receiving applications from individuals who can demonstrate research excellence focused on the molecular cell biology of health, disease and ageing with a view to translating outcomes into novel therapeutic approaches.  Applicants with a focus on the biology of membranes in these settings are particularly encouraged to apply.  All applicants must demonstrate an alignment with our existing research programmes and, for the senior positions, be able to lead and strengthen our research through their addition to our team.

Applicants should also be able to demonstrate a track record of effective teaching commensurate with career stage and an enthusiasm for flexible teaching across the range of programmes (UG: Biochemistry, Biological and Biomedical Sciences; PG: MSc Stem Cells & Regenerative Medicine; Biosciences MRes; Level 7 Research Scientist Degree Apprenticeship). Experience of teaching in areas such as physiology, metabolism, stem cells and regenerative medicine, molecular genetics, and protein science would be advantageous.

 Any application must be able to demonstrate your necessary teamwork skills to foster collaboration with existing Biosciences colleagues and to build links both within the University and externally, including the aptitude and ability to engage in continuous professional development.

You should clearly state how your appointment will build critical mass within the School and support the University mission through high quality, exploitable research that is accessible for business and has a positive impact on society.  

You can apply for these positions by clicking on the relevant link below:

Lecturer/Senior Lecturer in Biosciences

Reader in Biosciences

Potential applicants may wish to contact the Head of Biosciences, Professor Andrew Devitt (a.devitt1@aston.ac.uk) and the Associate Dean for Research, Professor Roslyn Bill (r.m.bill@aston.ac.uk) for informal discussion about the post before applying. Our web site at http://www1.aston.ac.uk/provides further details about the College of Health & Life Sciences


Research Fellow (Post Doctorial) – Extracellular Vesicles in Cancer (EVIC) – Trinity College Dublin – 7th May 2022 closing

Full-time; Fixed-term for June 2022 – Sept 2024

Salary Appointment will be made on the IUA Post-Doctoral Researcher Level 2 Point 1 with annual increment in line with Government Pay Policy.

Prof Lorraine O’Driscoll Group, School of Pharmacy & Pharmaceutical Sciences, Trinity Biomedical Sciences Institute & Trinity St. James Cancer Institute (https://www.tcd.ie)

Our research group (the O’Driscoll group) at Trinity College Dublin has extensive
experience in research of exosomes and other extracellular vesicles (collectively termed EVs). EVs
are emerging as important players in cell-to-cell communication under physiological and
pathological circumstances. Some studies have suggested significantly more EVs in cancer
patients’ blood compared to healthy controls; other have not. We hypothesis that this conflict in
observation may be due to EVs’ heterogenous nature. Furthermore, for patients about to start
neo-adjuvant treatment, we observed that small EVs (sEV) concentrations are great for non-
responder partial responder; complete responders; controls. Here we will more comprehensively investigate sEVs’ relevance. In vitro and in vivo studies across several solid tumour types implicate EVs released from cancer cells as causally involved in invasion, angiogenesis, metastasis, and drug- resistance. Previous attempts to block EV release, and so these consequences, have been hampered by the approaches used also affecting EV release from normal cells that may be important for physiological events. However, we have now established that the microenvironment of the tumour substantially contributes to EV release. EVIC will thus investigate this, in efforts to prevent metastasis and drug-resistance. But not all EVs are bad! We have successfully isolated EVs from normal mesenchymal stem cells (MSCs) with potential as drug/miRNA delivery vehicles. This will be further explored.

Standard Duties and Responsibilities of the Post

  • Conduct a specified programme of research under the direction and mentorship of Prof.
    O’Driscoll
  • Deliver research outputs and provide input into reports as required for the project
    management schedule
  • Assist in identifying and developing future research and funding initiatives
  • Engage in the dissemination of the results of the research in which s/he is engaged, with
    the support of and under the supervision of Prof. O’Driscoll

Funding source: The funding for this project entitled Extracellular Vesicles in Cancer (EVIC) was
awarded to Prof O’Driscoll as an Irish Research Council Advanced Laurate (IRCAL).  

Person Specification: The Post-Doctoral Fellow appointed to this post will conduct cellular and
molecular research related to EVIC, assist with the day-to-day running of this project, assist with
supervising the research of two PhD students, assist with preparing timely reports for IRC and
other appropriate forms of dissemination from this study.

Qualifications: The candidate will hold a PhD in a pharmacology, bio-engineering, biotechnology, biochemistry, immunology, molecular biology, biotechnology or pharmacy.

Knowledge & Experience (Essential)
Cancer research
Mammalian cell culture
Working with extracellular vesicles
Basic laboratory techniques such as immunoblotting, qPCR, ELISAs
Data analysis

Knowledge &  Experience (Desirable)
Hypoxia, pre-clinical in vivo studies, drug delivery, working with plasma samples, confocal
microscopy, flow cytometry, proteomics, next-generation sequencing,
strong publication record, consistent with career stage

Skills &Competencies
– well organised, able to maintain overview and excellent planning and organisational skills
results- and solution-oriented
– excellent scientific writing and spoken (in English) skills
– proactive, enthusiastic, motivated, flexible and problem-solving attitude
– proven excellent communication skills
– able to work independently and as a member of a team
– good computer/IT skills

Application Procedure

Applicants should submit (i) a Cover Letter outlining your suitability for this position and
(ii) a full Curriculum Vitae including the names and contact details of 3 referees (including email addresses), to:- Prof. Lorraine O’Driscoll – lodrisc@tcd.ie

Ensure to use EV-Hypoxia Post-Doc. and your name in the email “Subject” box


Research Associate – Extracellular Vesicles Therapeutics for Bone Regeneration – Loughborough University – 31st Jan 22 closing date – £31,406

Full information at: https://www.jobs.ac.uk/job/CLZ487/research-associate-extracellular-vesicles-therapeutics-for-bone-regeneration

Full-time; Fixed-term for 26-months

We are seeking applications from individuals with a background in extracellular vesicle (EV) science, bone biology/chemistry or materials science for an exciting multidisciplinary EPSRC-funded project. The overarching aim of the project is to develop a unique regenerative platform technology for the co-ordinated delivery of bioinstructive cell-derived EVs to enhance bone regeneration. The research will contribute toward the ongoing development of a range of pioneering EV therapeutics. The project feature collaborations with academics at the Universities of Glasgow and Nottingham, as well as industry partners. The appointed candidate will be expected to spend some of their time working at these collaborating institutions. Candidates with a research background in bone biology/chemistry and materials science are strongly encouraged to apply.

This full-time post is offered on a fixed-term contract for 26-months, starting 1st March 2022 or as soon as possible thereafter.

Informal enquiries should be directed to Dr Owen Davies, Senior Lecturer in Molecular and Regenerative Biomedicine, via email to O.G.Davies@lboro.ac.uk

Closing date for applications:  31 January 2022.

Please follow this link for further information.


Lecturer (full time) – University of Sheffield, School of Clinical Dentistry – 9th Jan 22 closing date – £42,149 to £50,296 per annum. 

Full information at: https://www.jobs.ac.uk/job/CLQ708/lecturer 

We are seeking to appoint a Lecturer to join the vibrant and supportive team in the School of Clinical Dentistry at the University of Sheffield (www.sheffield.ac.uk/dentalschool). Our ideal candidate will be a talented and enthusiastic team member ready to support the delivery of undergraduate teaching and postgraduate programmes and conduct internationally competitive research including high-quality PGR supervision.

You will also play a key role in delivering and enhancing our highly regarded undergraduate and postgraduate taught programmes, including our BSc in Bio-dental Science and Technology and Bachelor of Dental Surgery (BDS) (www.sheffield.ac.uk/dentalschool/undergraduate/undergraduate-courses). We particularly encourage applications from those able to contribute to the teaching of biochemistry, molecular biology, basic physiology and cell biology.

The position will be based in the School of Clinical Dentistry, a world-leading interdisciplinary centre for oral and dental research with a focus on translating research for patient benefit. You will benefit from a supportive research environment with core technical support and access to world-class laboratory facilities. The School hosts a vibrant postgraduate research community, and has strong links to centres of research excellence across The University of Sheffield, providing access to state-of-the-art imaging, molecular biology, bioinformatics and biological services facilities.

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

To find out what makes the University of Sheffield a remarkable place to work, watch this short film: www.youtube.com/watch?v=7LblLk18zmo, and follow @sheffielduni and @ShefUniJobs on Twitter for more information.


Research Fellow (full time) – EGA Institute for Women’s Health, UCL – 5th Dec 2021 closing date – Start 1st Jan 2022

£36,770 per annum

Applicants are invited for a Research Fellow position in an exciting research programme held at the newly built Zayed Centre for Research into Rare Disease in Children, on developing innovative treatments for neonatal hypoxia ischemia encephalopathy (NE) using small extracellular vesicles. The efficacy of EVs will be assessed in vitro.
 
The aim of the research is to explore the neuro-protective effects of EVs with the view to develop cell-free therapeutics for the treatment of NE and overcome the hurdles associated with the injection of live stem cells. The duties of the post include (1) isolating/characterizing EVs; (2) using a NE in vitro model to determine the phenotypic effects of iEV treatment on recipient brain cells in vitro.
 
The post is funded for 3 years in the first instance and is available 1st January 2022.
 
Key Requirements
Applicants must have a higher degree in a relevant discipline at a PhD level (if degree has not yet been granted, the final accepted version of the thesis should have been submitted to the degree granting university by the time of starting) as well as the necessary experience and skills to carry out the work. Previous experience with isolation and characterisation of small extracellular vesicles (EVs) released by human cells is essential. Experience with human stem cell culture is an advantage. 
 
Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B (salary £32,217 – £33,958 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis.
 
Further Details
A job description and person specification can be accessed at the bottom of this page.
 
To apply for the vacancy please click on the ‘Apply Now’ button below on this link: click here 
 
If you have any queries regarding the vacancy, please contact Dr. Pascale V Guillot, p.guillot@ucl.ac.uk.
If you have any queries regarding the application process please contact HR Administrator at IfWH Aqsa Andaloussi, a.hjiej-andaloussi@ucl.ac.uk.
 
UCL Taking Action for Equality – We will consider applications to work on a part-time, flexible and job share basis wherever possible.
 
Closing Date: 5 Dec 2021
Latest time for the submission of applications: 23.59
Interview date: TBC
 

 

Research Officer (full time) – Swansea University Medical School – 3rd November 2021

£35,326 to £37,467 per annum (pro-rata if part time), together with USS pension benefits. 

We are seeking a highly talented and enthusiastic post-doctoral research scientist to join the newly formed EV Biology Research Group, working on an exciting new project titled “Extracellular Vesicle Glycoproteins for Prostate Cancer Diagnosis (EVGlyProD)”. The project is led by Dr Jason Webber (Swansea University Medical School) and is funded by Cancer Research UK.

When diagnosing patients with prostate cancer, it is difficult to discriminate patients with slow growing tumours from those with clinically significant, aggressive, disease who require urgent treatment. Currently, doctors rely on tissue biopsy, which is an invasive procedure with potential for numerous complications. There remains an unmet need for a simple, non-invasive, assay for diagnosis of prostate cancer. This project is focussed on the development of a blood-based test, to detect glycoproteins present on the surface of extracellular vesicles, and development of a multiplexed assay for identification of patients with clinically significant disease without the need for invasive biopsy. This will involve collaboration with researchers locally, at Cardiff University and Swansea Bay University Health Board, and further afield.

Applicants should have a PhD degree in a biomedical science subject and relevant laboratory experience. Laboratory experience must include immunoaffinity-based assays (e.g. ELISA) and evidence of assay refinement. In addition, you must experience in the conduct, interpretation and reporting of qualitative and quantitative research. Evidence of excellent organisational skills, with an appreciation of management of clinical samples (and corresponding data) is essential. Further experience working with EVs and / or clinical samples is of further benefit.

For informal enquiries, please contact Dr Jason Webber – j.p.webber@swansea.ac.uk.

For more information: https://www.swansea.ac.uk/jobs-at-swansea/current-vacancies/details/?nPostingId=100818&nPostingTargetId=129052&id=QHUFK026203F3VBQB7VLO8NXD&LG=UK&mask=suext

 


Lecturer

University of Sheffield – Faculty of Medicine, Dentistry and Health – School of Clinical Dentistry – Closes 6th Oct 21

We are seeking to appoint a Lecturer to join the vibrant and supportive team in the School of Clinical Dentistry at the University of Sheffield (www.sheffield.ac.uk/dentalschool). Our ideal candidate will be a talented and enthusiastic team member ready to support the delivery of undergraduate teaching and postgraduate programmes and conduct internationally competitive research including high-quality PGR supervision.

We are looking for an outstanding scientist with research interests complementing and enhancing the research strategy of the department and wider university. Applications from candidates whose research interests align with those of the recently established Neuroscience (www.sheffield.ac.uk/neuroscience-institute) and/or Healthy Lifespan (www.sheffield.ac.uk/healthy-lifespan) University Research Institutes are particularly encouraged, but applications will be considered from those with interests and experience aligning with any of the School’s research priorities. We encourage applications from those with experience in sensory neuroscience research at the molecular or systems level. The post-holder will also play a key role in delivering and enhancing our highly regarded undergraduate and postgraduate taught programmes, particularly our BSc in Bio-dental Science and Technology and Bachelor of Dental Surgery (BDS) (www.sheffield.ac.uk/dentalschool/undergraduate/undergraduate-courses). We particularly encourage applications from those able to contribute to the teaching of physiology, pharmacology, neuroscience and molecular research techniques.

The position will be based in the School of Clinical Dentistry, a world-leading interdisciplinary centre for oral and dental research with a focus on translating research for patient benefit. You will benefit from a supportive research environment with core technical support and access to world-class laboratory facilities. The School hosts a vibrant postgraduate research community, and has strong links to centres of research excellence across The University of Sheffield, providing access to state-of-the-art imaging, molecular biology, bioinformatics and biological services facilities.

We’re one of the best not-for-profit organisations to work for in the UK. The University’s Total Reward Package includes a competitive salary, a generous Pension Scheme and annual leave entitlement, as well as access to a range of learning and development courses to support your personal and professional development.

We build teams of people from different heritages and lifestyles from across the world, whose talent and contributions complement each other to greatest effect. We believe diversity in all its forms delivers greater impact through research, teaching and student experience.

To find out what makes the University of Sheffield a remarkable place to work, watch this short film: www.youtube.com/watch?v=7LblLk18zmo, and follow @sheffielduni and @ShefUniJobs on Twitter for more information.


Masters by Research project on Covid-19 particles

Canterbury Christ Church University – closing 8th August 21

The School of Life Sciences at Canterbury Christ Church University (CCCU) welcomes applications for a new Masters by Research degree scholarship. A unique opportunity for a fully funded and industry-led MSc to develop novel strategies to challenge and prevent the spread of communicable diseases. This MSc by Research in Bioscience will tackle and provide novel solutions for the current COVID-19 pandemic under the guidance of leading industry experts in Biochemistry, Micro- and Cell Biology. This course will give you a unique opportunity to study strategies to combat the spread of potentially infectious agents while developing laboratory skills in Molecular Cell Biology and Biochemistry.

As this is a research-focused master’s course, it will provide an interactive approach to learning and allow you to develop independent skills in the lab. In addition, the Master will be supported through seminars and workshops to help develop skills that can be applied to your own research project.

Anticipated start date: 1 October 2021

Closing date for applications: 8 August 2021

Interviews: August 2021. Exact date to be confirmed.

The Award

The scholarship is for one year full time study. Scholarships comprise a stipend of £12,000 per year, and a full time MSc by Research tuition fee waiver.

Entry Requirements:

Candidates should hold at least an Upper Second Class Undergraduate Honours degree, and have a strong commitment to the development of a research career within Biosciences.

It is desirable that candidates have skills in chromatography, electrophoresis, protein and nucleic acid biochemistry.

We endeavour to be inclusive and flexible regarding applicants with caring obligations, disabilities and other considerations.

How to Apply:

Applications should be made for the MSc by Research programme through Canterbury Christ Church University’s online application system by clicking on the ‘apply now’ button.

In applying online applicants should select the MSc by Research programme in the School of School of Psychology and Life Sciences, studying full-time, with a start date of 1 October 2021.

Further enquiries:

For other questions or queries please do not hesitate to contact Dr Cornelia Wilson (cornelia.wilson@canterbury.ac.uk) or Dr Lee Byrne (lee.byrne@canterbury.ac.uk).


PhD studentship: ‘ Bacteriophage therapy against antibiotic resistant airway pathogenic bacteria’

London Metropolitan University – closing Tuesday 20 July 2021

London Metropolitan University is inviting candidates to apply for a fully funded Postgraduate Scholarship for a period of up to four years with full-time support to complete a PhD on the topic of: Bacteriophage therapy against antibiotic resistant airway pathogenic bacteria. There is a rapidly developing and very serious worldwide crisis of bacterial resistance to antibiotics which has been recently highlighted in immunosuppressed COVID-19 patients with secondary bacterial infections. This is especially found in antibiotic resistant biofilm-forming airway pathogenic bacteria exacerbating overall disease pathology.

This project will use bacteriophage (phage) therapy as an alternative to antibiotics. The success of this approach will find ways to overcome two mechanisms bacteria have to resist lytic phage: (a) shedding bacterial vesicles as phage decoys and (b) biofilm formation. The project aims to attenuate bacterial vesicle release to make phage therapy a more viable alternative to antibiotic therapy. As respiratory bacteria associated with SARS-CoV-2 infection form biofilms and as in other work we have found bacterial vesicles to be mediators of biofilm formation, inhibition of vesicle release will also therefore weaken the protective barrier biofilms impart, enabling phage easier access to lyse bacteria.

For informal enquiries about the project, please contact: Prof. Jameel Inal j.inal@londonmet.ac.uk

All successful candidates should have an excellent degree in a Life Sciences subject. An excellent master’s degree will be considered highly desirable. Those with alternative professional or occupational experience will also be considered in lieu of master’s level qualifications. Candidates should contribute to our race equity agenda and enhance our intellectual life; they will be given the opportunity to interact with students (as tutors, lecturers, or mentors).

Benefits: The successful candidates will be supported to achieve Associate Fellow status with the Higher Education Academy and will have access to the necessary teaching experience to achieve this. Those who are offered a post will also be given support to attend conferences and publish papers.

All candidates must provide:

  • A 300-500 word proposal that directly addresses the contribution they will make to the particular project. Candidates may only apply for one project.
  • A 200-word statement describing their values in relation to equity and values
  • A PDF/scanned proof of their qualifications
  • Proof of eligibility to study in the UK (eg passport scan)

Candidates are required to email their applications to rpo@londonmet.ac.uk by 5pm on Tuesday 20 July 2021. Candidates may only apply for a total of one project and must be available to start in October 2021. This is a full-time studentship. 

Funding: Each scholarship will come with a fee waiver and a stipend of £17,900 per annum, a figure that is based on a London Living Wage rate of £10.89 per hour for 37 hours per week and 52 weeks per year net. This funding will be available for a maximum of four years.

 

PhD studentship: ‘Regulatory T Cell-derived Extracellular Vesicles in Patients with Rheumatoid Arthritis: A Cell-Free Modality for Suppression of Inflammation’ 

Keele University (at the RJAH Orthopaedic Hospital) – Closing 31 August 2021

Funding is available to cover 100% UK student tuition fees and consumables for 3 years.

One in every 16 of people in the UK live with an autoimmune condition causing them pain, difficulty, lost opportunities in work and in life, and in many cases placing them at risk of early death.  Autoimmunity occurs when the immune system attacks the body. Regulatory cells (also called Tregs) are cells of immune system which have a role in regulating or suppressing other cells in the immune system. Tregs control the immune response to self and foreign particles and help prevent autoimmune disease. Understanding how Tregs supress cells in the immune system could help improve treatments for people with autoimmune conditions including lupus, type 1 diabetes, Sjögren syndrome, multiple sclerosis and rheumatoid arthritis. In rheumatoid arthritis, the immune system destroys the lining of the joints. At present, autoimmune conditions cannot be cured. Tregs communicate with other cells in the immune system by producing the little particles called extracellular vesicles. This project will explore these particles to find out what’s inside them and how they differ in healthy people and patients with rheumatoid arthritis using a variety of different tests. Next, this project will explore how the extracellular vesicles function. We will add the particles into a dish with immune cells from patients with rheumatoid arthritis. These cells are overactive, which causes the pain, inflammation and swelling in the joints, so we want to see if our extracellular vesicles can suppress these immune cells. If these experiments are successful and the extracellular vesicles contain anti-inflammatory properties, then they have the potential to be applied to many different autoimmune conditions. 

CD4+CD25+/highCD127low/− regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance, by preventing autoimmunity and chronic inflammation. In this project we would like to explore whether the biological characteristics and functionality of regulatory T cell-derived extracellular vesicles in patients with rheumatoid arthritis differed from those in healthy donors.

We aim to investigate immunoregulatory functional properties of Tregs-derived  EVs in rheumatoid arthritis patients and healthy volunteers.

This project provides the opportunity to work closely with researchers at different Universities, clinicians and human patient samples/data to address a pertinent clinical question that will likely lead to patient benefit. The studentship will be based at the RJAH Orthopaedic Hospital in Oswestry, however, there will be the occasional need to attend training at Keele University, Cardiff University and the University of East London.

Source of funding: The Institute of Orthopaedics, Ltd

Entry Requirements: This PhD is suitable for UK students with a degree in the biological/natural sciences – minimum degree classification 2i. Non-UK applicants will be considered if they are able to self-fund any additional tuition fee costs that may exist and can obtain a visa to study in the UK.

An interest in regenerative medicine, immunology and some experience in tissue culture techniques is desirable.  

Closing date for applications:     31th August 2021

Application process: Go to http://www.keele.ac.uk/pgresearch/studentships/ and click on the “Apply” button in this studentship.

https://www.findaphd.com/phds/project/regulatory-t-cell-derived-extracellular-vesicles-in-patients-with-rheumatoid-arthritis-a-cell-free-modality-for-suppression-of-inflammation/?p133543

For any further information or for an informal chat about the project please contact: Dr Oksana Kehoe on o.kehoe@keele.ac.uk


 

Research Officer (full time) – Swansea University Medical School – 19th July 2021

Salary £34,804 to £40,322 per annum (Grade 8). This post is full-time (35 hours per week), fixed-term until 31st July 2022 (possibility of extension subject to funding).

We are seeking a highly talented and enthusiastic post-doctoral research scientist to join the newly formed EV Biology Research Group, working on an exciting new project titled “Making a difference in prostate cancer: developing a new blood-based test for early diagnosis of aggressive prostate cancer”. The project is led by Dr Jason Webber (Swansea University Medical School) and is funded by Cancer Research Wales.

When diagnosing patients with prostate cancer, it is difficult to discriminate patients with slow growing tumours from those with clinically significant, aggressive, disease who require urgent treatment. Currently, doctors rely on tissue biopsy, which is an invasive procedure with potential for numerous complications. There remains an unmet need for a simple, non-invasive, assay for diagnosis of prostate cancer. This project is focussed on the development of a blood-based test, to detect RNAs contained within extracellular vesicles, capable of identifying patients with slow growing disease or those with aggressive prostate cancer, thus limiting the need for invasive biopsy. This will involve collaboration with researchers locally, at Cardiff University and the Wales Gene Park, and further afield.

Applicants should have a PhD degree in a biomedical science subject and relevant laboratory experience. Laboratory experience must include RNA isolation and real time PCR. In addition, you must experience in the conduct, interpretation and reporting of qualitative and quantitative research. Evidence of excellent organisational skills, with an appreciation of management of clinical samples (and corresponding data) is essential. Further experience working with EVs and / or clinical samples, as well as analysis of RNAseq data is of further benefit.

For informal enquiries, please contact Dr Jason Webber – j.p.webber@swansea.ac.uk.

For more information: https://www.swansea.ac.uk/jobs-at-swansea/current-vacancies/details/?nPostingID=92738&nPostingTargetID=116152&ID=QHUFK026203F3VBQB7VLO8NXD&lg=UK&mask=suext


Senior Scientist, Genetic Engineering – STRM.BIO, Cambridge, MA, USA

STRM.BIO (pronounced “storm bio”) is a pre-clinical, VC-backed biotechnology company that is leveraging naturally-derived extracellular vesicles (EVs) to deliver gene therapies in vivo. We believe in a culture where people come first and that personal accountability is key to a healthy organization. We believe that there is both elegance and efficiency in simplicity, and we let this approach drive both our science and our strategy.

STRM.BIO is operating on a hybrid-virtual model. We are leveraging the existing laboratory infrastructure and expertise of our scientific collaborators, contract development and manufacturing organizations (CDMOs), and advisors to focus on what matters–our research. Meetings are mostly virtual, but teams will meet in person to whiteboard strategy, visit partners to advance programs, and celebrate our wins! We are assembling a team of leaders who share our company values, who believe in the promise of EVs to bring transformative therapies to patients, and who will actively contribute to a culture of continuous learning, innovative discovery, and unyielding commitment to high quality science.

THE TECHNOLOGY
STRM.BIO is creating a proprietary EV platform to deliver gene therapies in vivo and establish a new class of therapeutics. EVs are natural carriers of nucleic acids and proteins and hold tremendous promise as direct cell messengers for gene therapies due to their innate targeting, amenability to large scale/commercial manufacture, and low immunogenicity. At STRM, we are aiming to create new therapies and uniquely enable
effective targeting of existing ones to democratize gene therapy. We are just beginning to explore the potential impact of our platform and are looking to recruit team members who can help us bring this larger vision to light.

The Senior Scientist position is full-time and will be predominantly remote, but you should be prepared to conduct in-person benchwork as needed. You will work directly with the STRM Director of Research to manage your scientific programs while providing critical scientific leadership and genetic engineering guidance. You should be very comfortable with coordination of multiple external academic and/or contract research groups, as this will be central to your management role.

To be successful in this role, you should be someone who is always up for a challenge and finds the unique demands of the fast-paced startup environment motivating. You will need to be adept at managing both projects and people, and be able to do both while espousing the people-first, simplicity-oriented values we hold as core to STRM culture.

KEY RESPONSIBILITIES

  • Support the Director or Research in managing, coordinating, and supporting the research
    efforts across multiple collaborative research programs
  • Oversee all genetics R&D efforts to meet project milestones, maintaining the standards of
    scientific rigor and adhering to ethical standards
  • Maintain standards consistent with company culture and values
  • Work closely with team members (internal and external) to guide project development, provide
    technical expertise for the design, implementation and troubleshooting of experiments, and
    ensure deliverables for both internal research projects and external scientific partnerships
  • Coordinate and oversee the generation, collection, and sharing of experimental results and
    ensure that all protocols, reagents, data, and analyses are documented following data integrity
    principles and prepared and made available in a timely manner
  • Attend and present at team meetings to share results, plan projects and experiments, and
    ensure that projects support team goals and company milestones
  • Represent STRM.BIO as a senior spokesperson at scientific, medical, regulatory, business and
    other professional meetings
  • Contribute to grant and proposal writing
  • Maintain comprehensive and up-to-date knowledge of extracellular vesicle biology,
    extracellular vesicles as therapeutics, and novel genetic engineering approaches
  • Perform other duties as assigned, including related lab management duties
  • PhD and 4+ years of postdoctoral experience in a relevant discipline with strong
    foundational knowledge of genetic engineering and cell culture background; experience
    in hematopoietic stem cell biology and hematologic diseases (preferred)
  • Hands-on experience in in vitro, ex vivo, and in vivo studies determining the efficacy of
    gene editing/gene therapy including quantification of editing efficiency/gene delivery,
    and effects on gene and protein expression in modified cells
  • Experience in genetic, molecular, and cellular biology techniques, including plasmid
    construction, qPCR, RT-PCR, western blotting, microscopy, multiplexed flow cytometry,
    and techniques to assess gene editing efficiency and off-target effects (e.g. NGS)
    Expertise in genome editing technologies, including CRISPR-based methods, baseediting,
    deletions and knock-ins and gene silencing
  • Working knowledge of other gene editing techniques (e.g. TALEN and ZFNs) and gene
    therapy delivery technologies (e.g. viral vectors, LNPs, exosomes)
  • Experience in design, synthesis, and evaluation of gene expression cassettes/constructs
  • Experience with mammalian cell culture (primary hematopoietic cell culture preferred)
    and mouse models of human disease
  • Experience managing remote teams and/or collaborations, and ability to build strong,
    collaborative relationships and lead and motivate team members
  • Ability to balance/prioritize research efforts across multiple programs, meet deadlines,
    and shift plans in service of a rapidly-changing startup environment
  • Proficiency with Microsoft Office suite, with excellent PowerPoint and Excel skills
  • Exceptional communication, writing, organizational and time management skills
  • Exemplary lab notebook practices, and attention to detail in recordkeeping; experience
    with electronic lab notebook (ELNs) preferred

KEY POSITION DETAILS

Full-time Position

  • Salary and benefits consistent with the competitive market of Boston/Cambridge and commensurate with experience
  • Remote position with potential need for in-person benchwork in
  • Boston/Cambridge area and/or at partner headquarters location(s)

To learn more about this position, please submit your resume and cover letter
directly to Dr. Jonathan Thon, CEO at careers@strm.bio


Tenure Track Professorship for Translational Inflammation Research with focus on Extracellular Vesicles – University of Marburg, Germany – open 

The University of Marburg is inviting early career researchers with outstanding academic achievements to apply for a Assistant/Associate Professorship for Translational Inflammation Research with focus on Extracellular Vesicles (tenured) with an attractive starter package (personnel, consumables, lab space).

We focus on lung diseases and sepsis, but also mucosal inflammation and infections, and provide access to established as well as innovative vesicle technologies (UZ, SEC, NTA, Nano-FCM, ExoView, Imaging-Flow Cytometry etc.) as well as core facilities for genomics, proteomics, metabolomics, imaging, cell sorting and structural biology. The immune response in inflammatory or infectious diseases will be studied in the context of human or bacterial extracellular vesicles. Research on human model systems (cell/tissue culture, organoids) and clinical material is desired. The institute is involved in the German Centres for Lung (DZL) and Infection Research (DZIF) as well as the Centre for Synthetic Microbiology (SYNMIKRO) and cooperates closely with the Max- Planck-Institute for Terrestrial Microbiology.

The call is primarily aimed at candidates (m/f/d) in an early career phase who have already achieved first visible successes in the field of inflammation research, infection biology or the biology of extracellular vesicles. Applicants must have completed a degree and hold an excellent doctorate in a scientific or biomedical subject. The duration of scientific activity after the doctorate should not exceed four years (seven years in the case of successful further medical training). The professorship is intended to strengthen the focus of the Faculty of Medicine in the field of infection, immunology and extracellular vesicles and to contribute to the current and planned DFG research consortia.

Further Information: Prof. Bernd Schmeck (bernd.schmeck@uni-marburg.de)


 

search previous next tag category expand menu location phone mail time cart zoom edit close