If you have any positions, and you’re a member, contact us by email (firstname.lastname@example.org) to advertise them below:
PhD studentship: ‘ Bacteriophage therapy against antibiotic resistant airway pathogenic bacteria’
London Metropolitan University – closing Tuesday 20 July 2021
London Metropolitan University is inviting candidates to apply for a fully funded Postgraduate Scholarship for a period of up to four years with full-time support to complete a PhD on the topic of: Bacteriophage therapy against antibiotic resistant airway pathogenic bacteria. There is a rapidly developing and very serious worldwide crisis of bacterial resistance to antibiotics which has been recently highlighted in immunosuppressed COVID-19 patients with secondary bacterial infections. This is especially found in antibiotic resistant biofilm-forming airway pathogenic bacteria exacerbating overall disease pathology.
This project will use bacteriophage (phage) therapy as an alternative to antibiotics. The success of this approach will find ways to overcome two mechanisms bacteria have to resist lytic phage: (a) shedding bacterial vesicles as phage decoys and (b) biofilm formation. The project aims to attenuate bacterial vesicle release to make phage therapy a more viable alternative to antibiotic therapy. As respiratory bacteria associated with SARS-CoV-2 infection form biofilms and as in other work we have found bacterial vesicles to be mediators of biofilm formation, inhibition of vesicle release will also therefore weaken the protective barrier biofilms impart, enabling phage easier access to lyse bacteria.
For informal enquiries about the project, please contact: Prof. Jameel Inal email@example.com
All successful candidates should have an excellent degree in a Life Sciences subject. An excellent master’s degree will be considered highly desirable. Those with alternative professional or occupational experience will also be considered in lieu of master’s level qualifications. Candidates should contribute to our race equity agenda and enhance our intellectual life; they will be given the opportunity to interact with students (as tutors, lecturers, or mentors).
Benefits: The successful candidates will be supported to achieve Associate Fellow status with the Higher Education Academy and will have access to the necessary teaching experience to achieve this. Those who are offered a post will also be given support to attend conferences and publish papers.
All candidates must provide:
- A 300-500 word proposal that directly addresses the contribution they will make to the particular project. Candidates may only apply for one project.
- A 200-word statement describing their values in relation to equity and values
- A PDF/scanned proof of their qualifications
- Proof of eligibility to study in the UK (eg passport scan)
Candidates are required to email their applications to firstname.lastname@example.org by 5pm on Tuesday 20 July 2021. Candidates may only apply for a total of one project and must be available to start in October 2021. This is a full-time studentship.
Funding: Each scholarship will come with a fee waiver and a stipend of £17,900 per annum, a figure that is based on a London Living Wage rate of £10.89 per hour for 37 hours per week and 52 weeks per year net. This funding will be available for a maximum of four years.
PhD studentship: ‘Regulatory T Cell-derived Extracellular Vesicles in Patients with Rheumatoid Arthritis: A Cell-Free Modality for Suppression of Inflammation’
Keele University (at the RJAH Orthopaedic Hospital) – Closing 31 August 2021
Funding is available to cover 100% UK student tuition fees and consumables for 3 years.
One in every 16 of people in the UK live with an autoimmune condition causing them pain, difficulty, lost opportunities in work and in life, and in many cases placing them at risk of early death. Autoimmunity occurs when the immune system attacks the body. Regulatory cells (also called Tregs) are cells of immune system which have a role in regulating or suppressing other cells in the immune system. Tregs control the immune response to self and foreign particles and help prevent autoimmune disease. Understanding how Tregs supress cells in the immune system could help improve treatments for people with autoimmune conditions including lupus, type 1 diabetes, Sjögren syndrome, multiple sclerosis and rheumatoid arthritis. In rheumatoid arthritis, the immune system destroys the lining of the joints. At present, autoimmune conditions cannot be cured. Tregs communicate with other cells in the immune system by producing the little particles called extracellular vesicles. This project will explore these particles to find out what’s inside them and how they differ in healthy people and patients with rheumatoid arthritis using a variety of different tests. Next, this project will explore how the extracellular vesicles function. We will add the particles into a dish with immune cells from patients with rheumatoid arthritis. These cells are overactive, which causes the pain, inflammation and swelling in the joints, so we want to see if our extracellular vesicles can suppress these immune cells. If these experiments are successful and the extracellular vesicles contain anti-inflammatory properties, then they have the potential to be applied to many different autoimmune conditions.
CD4+CD25+/highCD127low/− regulatory T cells (Tregs) play a crucial role in maintaining peripheral tolerance, by preventing autoimmunity and chronic inflammation. In this project we would like to explore whether the biological characteristics and functionality of regulatory T cell-derived extracellular vesicles in patients with rheumatoid arthritis differed from those in healthy donors.
We aim to investigate immunoregulatory functional properties of Tregs-derived EVs in rheumatoid arthritis patients and healthy volunteers.
This project provides the opportunity to work closely with researchers at different Universities, clinicians and human patient samples/data to address a pertinent clinical question that will likely lead to patient benefit. The studentship will be based at the RJAH Orthopaedic Hospital in Oswestry, however, there will be the occasional need to attend training at Keele University, Cardiff University and the University of East London.
Source of funding: The Institute of Orthopaedics, Ltd
Entry Requirements: This PhD is suitable for UK students with a degree in the biological/natural sciences – minimum degree classification 2i. Non-UK applicants will be considered if they are able to self-fund any additional tuition fee costs that may exist and can obtain a visa to study in the UK.
An interest in regenerative medicine, immunology and some experience in tissue culture techniques is desirable.
Closing date for applications: 31th August 2021
Application process: Go to http://www.keele.ac.uk/pgresearch/studentships/ and click on the “Apply” button in this studentship.
For any further information or for an informal chat about the project please contact: Dr Oksana Kehoe on email@example.com
Research Officer (full time) – Swansea University Medical School – 19th July 2021
Salary £34,804 to £40,322 per annum (Grade 8). This post is full-time (35 hours per week), fixed-term until 31st July 2022 (possibility of extension subject to funding).
We are seeking a highly talented and enthusiastic post-doctoral research scientist to join the newly formed EV Biology Research Group, working on an exciting new project titled “Making a difference in prostate cancer: developing a new blood-based test for early diagnosis of aggressive prostate cancer”. The project is led by Dr Jason Webber (Swansea University Medical School) and is funded by Cancer Research Wales.
When diagnosing patients with prostate cancer, it is difficult to discriminate patients with slow growing tumours from those with clinically significant, aggressive, disease who require urgent treatment. Currently, doctors rely on tissue biopsy, which is an invasive procedure with potential for numerous complications. There remains an unmet need for a simple, non-invasive, assay for diagnosis of prostate cancer. This project is focussed on the development of a blood-based test, to detect RNAs contained within extracellular vesicles, capable of identifying patients with slow growing disease or those with aggressive prostate cancer, thus limiting the need for invasive biopsy. This will involve collaboration with researchers locally, at Cardiff University and the Wales Gene Park, and further afield.
Applicants should have a PhD degree in a biomedical science subject and relevant laboratory experience. Laboratory experience must include RNA isolation and real time PCR. In addition, you must experience in the conduct, interpretation and reporting of qualitative and quantitative research. Evidence of excellent organisational skills, with an appreciation of management of clinical samples (and corresponding data) is essential. Further experience working with EVs and / or clinical samples, as well as analysis of RNAseq data is of further benefit.
For informal enquiries, please contact Dr Jason Webber – firstname.lastname@example.org.
Senior Scientist, Genetic Engineering – STRM.BIO, Cambridge, MA, USA
STRM.BIO (pronounced “storm bio”) is a pre-clinical, VC-backed biotechnology company that is leveraging naturally-derived extracellular vesicles (EVs) to deliver gene therapies in vivo. We believe in a culture where people come first and that personal accountability is key to a healthy organization. We believe that there is both elegance and efficiency in simplicity, and we let this approach drive both our science and our strategy.
STRM.BIO is operating on a hybrid-virtual model. We are leveraging the existing laboratory infrastructure and expertise of our scientific collaborators, contract development and manufacturing organizations (CDMOs), and advisors to focus on what matters–our research. Meetings are mostly virtual, but teams will meet in person to whiteboard strategy, visit partners to advance programs, and celebrate our wins! We are assembling a team of leaders who share our company values, who believe in the promise of EVs to bring transformative therapies to patients, and who will actively contribute to a culture of continuous learning, innovative discovery, and unyielding commitment to high quality science.
STRM.BIO is creating a proprietary EV platform to deliver gene therapies in vivo and establish a new class of therapeutics. EVs are natural carriers of nucleic acids and proteins and hold tremendous promise as direct cell messengers for gene therapies due to their innate targeting, amenability to large scale/commercial manufacture, and low immunogenicity. At STRM, we are aiming to create new therapies and uniquely enable
effective targeting of existing ones to democratize gene therapy. We are just beginning to explore the potential impact of our platform and are looking to recruit team members who can help us bring this larger vision to light.
The Senior Scientist position is full-time and will be predominantly remote, but you should be prepared to conduct in-person benchwork as needed. You will work directly with the STRM Director of Research to manage your scientific programs while providing critical scientific leadership and genetic engineering guidance. You should be very comfortable with coordination of multiple external academic and/or contract research groups, as this will be central to your management role.
To be successful in this role, you should be someone who is always up for a challenge and finds the unique demands of the fast-paced startup environment motivating. You will need to be adept at managing both projects and people, and be able to do both while espousing the people-first, simplicity-oriented values we hold as core to STRM culture.
- Support the Director or Research in managing, coordinating, and supporting the research
efforts across multiple collaborative research programs
- Oversee all genetics R&D efforts to meet project milestones, maintaining the standards of
scientific rigor and adhering to ethical standards
- Maintain standards consistent with company culture and values
- Work closely with team members (internal and external) to guide project development, provide
technical expertise for the design, implementation and troubleshooting of experiments, and
ensure deliverables for both internal research projects and external scientific partnerships
- Coordinate and oversee the generation, collection, and sharing of experimental results and
ensure that all protocols, reagents, data, and analyses are documented following data integrity
principles and prepared and made available in a timely manner
- Attend and present at team meetings to share results, plan projects and experiments, and
ensure that projects support team goals and company milestones
- Represent STRM.BIO as a senior spokesperson at scientific, medical, regulatory, business and
other professional meetings
- Contribute to grant and proposal writing
- Maintain comprehensive and up-to-date knowledge of extracellular vesicle biology,
extracellular vesicles as therapeutics, and novel genetic engineering approaches
- Perform other duties as assigned, including related lab management duties
- PhD and 4+ years of postdoctoral experience in a relevant discipline with strong
foundational knowledge of genetic engineering and cell culture background; experience
in hematopoietic stem cell biology and hematologic diseases (preferred)
- Hands-on experience in in vitro, ex vivo, and in vivo studies determining the efficacy of
gene editing/gene therapy including quantification of editing efficiency/gene delivery,
and effects on gene and protein expression in modified cells
- Experience in genetic, molecular, and cellular biology techniques, including plasmid
construction, qPCR, RT-PCR, western blotting, microscopy, multiplexed flow cytometry,
and techniques to assess gene editing efficiency and off-target effects (e.g. NGS)
Expertise in genome editing technologies, including CRISPR-based methods, baseediting,
deletions and knock-ins and gene silencing
- Working knowledge of other gene editing techniques (e.g. TALEN and ZFNs) and gene
therapy delivery technologies (e.g. viral vectors, LNPs, exosomes)
- Experience in design, synthesis, and evaluation of gene expression cassettes/constructs
- Experience with mammalian cell culture (primary hematopoietic cell culture preferred)
and mouse models of human disease
- Experience managing remote teams and/or collaborations, and ability to build strong,
collaborative relationships and lead and motivate team members
- Ability to balance/prioritize research efforts across multiple programs, meet deadlines,
and shift plans in service of a rapidly-changing startup environment
- Proficiency with Microsoft Office suite, with excellent PowerPoint and Excel skills
- Exceptional communication, writing, organizational and time management skills
- Exemplary lab notebook practices, and attention to detail in recordkeeping; experience
with electronic lab notebook (ELNs) preferred
KEY POSITION DETAILS
- Salary and benefits consistent with the competitive market of Boston/Cambridge and commensurate with experience
- Remote position with potential need for in-person benchwork in
- Boston/Cambridge area and/or at partner headquarters location(s)
To learn more about this position, please submit your resume and cover letter
directly to Dr. Jonathan Thon, CEO at email@example.com
Tenure Track Professorship for Translational Inflammation Research with focus on Extracellular Vesicles – University of Marburg, Germany – open
The University of Marburg is inviting early career researchers with outstanding academic achievements to apply for a Assistant/Associate Professorship for Translational Inflammation Research with focus on Extracellular Vesicles (tenured) with an attractive starter package (personnel, consumables, lab space).
We focus on lung diseases and sepsis, but also mucosal inflammation and infections, and provide access to established as well as innovative vesicle technologies (UZ, SEC, NTA, Nano-FCM, ExoView, Imaging-Flow Cytometry etc.) as well as core facilities for genomics, proteomics, metabolomics, imaging, cell sorting and structural biology. The immune response in inflammatory or infectious diseases will be studied in the context of human or bacterial extracellular vesicles. Research on human model systems (cell/tissue culture, organoids) and clinical material is desired. The institute is involved in the German Centres for Lung (DZL) and Infection Research (DZIF) as well as the Centre for Synthetic Microbiology (SYNMIKRO) and cooperates closely with the Max- Planck-Institute for Terrestrial Microbiology.
The call is primarily aimed at candidates (m/f/d) in an early career phase who have already achieved first visible successes in the field of inflammation research, infection biology or the biology of extracellular vesicles. Applicants must have completed a degree and hold an excellent doctorate in a scientific or biomedical subject. The duration of scientific activity after the doctorate should not exceed four years (seven years in the case of successful further medical training). The professorship is intended to strengthen the focus of the Faculty of Medicine in the field of infection, immunology and extracellular vesicles and to contribute to the current and planned DFG research consortia.
Further Information: Prof. Bernd Schmeck (firstname.lastname@example.org)