Available Positions

If you have any positions, and you’re a member, contact us by email (web@ukev.org.uk) to advertise them below:

PhD Studentship: Deciphering Molecular Crosstalk in the Musculoskeletal System: Vesicle-mediated Communication and its Impact on Bone Health

Start date of studentship: 01/07/2019  Closing date of advert: 22/04/19

Interview date: Late May

Supervisors: 

Primary supervisor: Dr Owen Davies

Secondary supervisor: Professor Mark Lewis

Short Introductory Paragraph

We are seeking a highly motivated candidate to work on an Academy of Medical Sciences funded PhD project that aims to understand how nano-vesicle-communication between muscle and bone impacts musculoskeletal health. It is anticipated that furthering our understanding of vesicle-based communication in the musculoskeletal system has the potential to inform the way we monitor and treat degenerative conditions such as osteoporosis (bone) and sarcopenia (muscle). The project features collaborations with international institutions including the Massachusetts Institute of technology (MIT, Boston) and the Myology Centre for Research (INSERM, Sorbonne University, Paris) and provides an opportunity for international placement.

Loughborough University is a top-ten rated university in England for research intensity (REF2014). In choosing Loughborough for your research, you’ll work alongside academics who are leaders in their field. You will benefit from comprehensive support and guidance from our Doctoral College, including tailored careers advice, to help you succeed in your research and future career.

Find out more: www.lboro.ac.uk/study/postgraduate/supporting-you/research

The School of Sport, Exercise and Health Sciences has been ranked 1st in the world for Sport-related Subjects (QS World University Rankings by Subject 2017, 2018 and 2019).

Full Project Detail:

Within our bodies, bone and muscle development is inextricably linked, with mechanical forces generated in the musculature having considerable impact on bone health. The relationship between these tissues is not solely mechanical but is also dependent on the release of proteins and nano-sized particles called extracellular vesicles (EVs) that provide a method of communication. Physical activity has a considerable role in maintaining overall musculoskeletal health by enhancing bone density and recent evidence has shown it modulates the release of EVs into the circulation. However, our current understanding of the contribution of these important nanoparticles to skeletal health is limited. By understanding how EVs contribute to bone maintenance we aim to develop a molecular means of monitoring skeletal health.

Find out more:

www.lboro.ac.uk/departments/ssehs/staff/owen-davies

Entry requirements:

Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) in molecular biology, biosciences or a related subject. A relevant Master’s degree and/or experience in one or more of the following will be an advantage: musculoskeletal biology, practical experience in extracellular vesicle (exosomes/microvesicles) isolation/analysis, tissue engineering.

Funding information:

The studentship is funded via an Academy of Medical Sciences Springboard award. The studentship will be awarded for 3 years and provides a tax-free stipend of £14,777 for the duration plus tuition fees at the UK/EU rate. Due to funding restrictions the studentship is only open to UK/EU students.

Contact details:

Name: Dr Owen Davies

Email address: O.G.Davies@lboro.ac.uk

How to apply:

All applications should be made online at http://www.lboro.ac.uk/study/apply/research/. Under programme name, select “School of Sport, Exercise and Health Sciences”.

Please quote reference number: SSEHS/OD


Funded 3 year PhD position – The studentship covers home/EU tuition fees (£4,260 in 2018/19) plus a generous stipend equivalent to the full UK Research Innovation rate of £14,777. – Sheffield Hallam University

Extracellular Vesicles: small packages with a big role in bowel cancer metastasis

Project details 
Background: Patients with metastatic colorectal cancer (CRC) have poor survival rates, reflecting the difficulty in treating advanced disease. The events that lead to CRC metastases establishing are poorly understood; recently it has been proposed that extracellular vesicles (EVs) condition metastatic sites through organ-specific uptake. This project will determine the molecular processes driving metastasis and the role of EVs, aiming to develop new treatment approaches for advanced disease and to support monitoring and diagnosis of metastatic CRC.

Aims: 1) Develop a detailed understanding of CRC metastasis. 2) Develop an understanding of how/why CRC metastasises to particular sites. 3) Determine how EVs contribute to CRC metastasis.

Methods: Organotypic models of metastatic sites will be developed, which will be analysed histologically, biomechanically, and proteomically to develop signatures linked to metastatic progression. Models will also be conditioned using EVs from CRC cells, and the impact of this conditioning on invasion and metastatic signatures will be assessed. Micro-RNA profiles of EVs will be characterised and linked to their effects. These effects will then be validated in CRC tissues.

Outcomes: We will develop molecular signatures of metastatic progression in vitro, linked to histological and biomechanical features of tissue remodelling. Identifying key pathways linked to metastasis and important site-specific features will provide a basis for treatment approaches. We will use molecular manipulation to assess the putative role of a key mediators of invasion identified in this profiling, including the important enzyme TG2. We will then link EV miRNA profiles to their effects, identifying potential biomarkers of metastasis.

Research Environment 
The project will benefit from extensive culture and 3D modelling facilities in the Biomolecular Sciences Research Centre, and MALDI-imaging technology in the Centre for Mass Spectrometry Imaging at SHU. Dr Peake and Professor Le Maitre are established researchers with vast experience of developing in vitro models of disease and will provide full training. Dr Cole is an expert in MALDI imaging and complementary analytical techniques which will be used to develop molecular signatures in the model. The student will also benefit from working with established collaborators at the University of Sheffield and the University of Southampton, who will provide support for extracellular vesicle isolation and analysis, and clinical samples for translational impact.
https://www.shu.ac.uk/research/specialisms/biomolecular-sciences-research-centre
https://www.shu.ac.uk/research/specialisms/biomolecular-sciences-research-centre/what-we-do/commercial-services/mass-spectrometry

Entry requirements 
Successful applicants will possess all of the attributes listed below.
• A first class or upper second class honours degree in cancer biology, molecular biology, cell biology, protein biology or a related discipline or a distinction at MSc. Experience working in a research laboratory for at least one year is desirable.
• Excellent communication skills in English (speaking and writing).
• Ability to work independently and within a team
• Highly motivated with a commitment to conduct high quality research
• Excellent time management skills

Funding NotesThis is a 3 year fully funded PhD studentship. The studentship covers home/EU tuition fees (£4,260 in 2018/19) plus a generous stipend equivalent to the full UK Research Innovation rate of £14,777.

This PhD is primarily funded by Bowel & Cancer Research, with additional support from the SHU “creating knowledge” collaborative PhD scheme.

Application Process 
Interested candidates should apply to Sheffield Hallam University via the University application form, including a 1500 word research proposal (section 9) demonstrating your background reading on the topic of the PhD and your plans for how you would undertake this programme of research. Additionally please include a covering letter describing why you are interested in pursuing postgraduate studies and how you meet the selection criteria.

An application form can be downloaded at the following URL:
https://www.shu.ac.uk/study-here/how-to-apply/postgraduate/application-form
For informal enquiries about the project please contact Dr Nick Peake: n.peake@shu.ac.uk

Key Dates: 
• Deadline for applications 31st March, 2019
• Interviews will be held in April
• Studentship to begin in May, or in exceptional circumstances, October.



The Oxford Interdisciplinary Bioscience Doctoral Training Partnership

  • If you wish to apply to the DTP via Oxford Brookes University please complete the Faculty of Health and Life Sciences PhD Research Studentship Application Form.

    Application and CV must be emailed to the addresses shown on the application form.

    The Oxford Interdisciplinary Bioscience Doctoral Training Partnership (DTP) programme is a 4-year DPhil*/PhD programme that aims to equip a new generation of researchers with the skills and knowledge needed to tackle the most important challenges in bioscience research.

    We provide an innovative, individually-tailored training programme that includes taught courses in interdisciplinary skills and the opportunity for students to undertake two exploratory research projects with prospective supervisors in their first year before choosing their main 3-year research project. Students also undertake a 12-week professional internship to gain direct experience of the areas of work into which they can apply their skills.

    Oxford Brookes University is offering a place on the BBSRC funded DTP within the Department of Biological & Medical Sciences in the areas of plant cell biology, virology, insect and spider development, mammalian cell biology, molecular biology, metabolic modelling/systems biology, parasitology and bioimaging. The successful candidate will enjoy access to our state of the art facilities, including newly refurbished laboratories and bioimaging suite.

    In addition to their choice of PhD project at Oxford Brookes University, the student will be able to undertake their exploratory research projects at any of the seven world-class research institutions that make up the DTP:


    The programme is supported by the Biotechnology and Biological Sciences Research Council (BBSRC) with additional support from within the Partnership. Please see below for potential supervisors and instructions on how to apply.

    OIBDT
    We have many projects available which can be taken as a short term (3-month) rotation or a full PhD project. The following supervisors are offering exciting projects; for further information click on the link to visit their lab website.

    Deadline for receipt of applications is for first round is 12 noon on 16th November 2018

    Eligibility criteria: Only open to UK applicants (who must be resident in UK)

    Start date: September/October 2019

    The Bursary for academic year 2019/20 will match the minimum bursary rate set by BBSRC, to note it is currently £14,777 for 2018/19.  

    Applicants require a good Honours degree level equivalent to a UK degree BSc (minimum 2.1 or higher).

    Any queries please contact:
    Prof David Carter: dcarter@brookes.ac.uk


Also try: www.findapostdoc.com, or https://academicpositions.com in the EU.

Those of you interested in the USA should check out: https://www.exosome-rna.com/tag/postdoc/

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