Research Fellow in Developing Immunocompetent Animal-free Models of Bowel Cancer
Sheffield Hallam University – College of Health Wellbeing & Life Science – Biomolecular Sciences Research Centre
| Location: | Sheffield |
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| Salary: | £39,906 to £46,049 dependent on experience (Grade 7) |
| Hours: | Full Time |
| Contract Type: | Fixed-Term/Contract |
| Placed On: | 2nd March 2026 |
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| Closes: | 29th March 2026 |
| Job Ref: | 116967 |
Job link: https://www.jobs.ac.uk/job/DQS094/research-fellow-in-developing-immunocompetent-animal-free-models-of-bowel-cancer
Fixed-term – for 24 months
Full time – 37 hours per week
The School of Biosciences and Chemistry are looking to appoint a Research Fellow in the Biomolecular Sciences Research Centre, working on a project funded by the Humane Research Trust to develop animal-free models for the testing of new immunotherapies in the treatment of bowel cancer. You will contribute to an ongoing programme of research geared towards the use of “human tissue to model human disease”, promoting the development of new methods to replace the use of animals in medical research and delivering solutions that are both more humane and support better scientific in an area where current models have poor translation into patients with bowel cancer.
You will take the lead on liaising with clinical collaborators, collection of clinical material, processing and development of cell models using patient-derived material. You’ll be supported to develop your own interests in this field, with a view to developing your own independent research career. You’ll work in a team committed to producing high quality research outputs in the form of academic publications, conference presentations, and lead in a field with growing influence over governmental policy around humane medical research.
We are seeking a candidate with experience in cell biology and practical skills in microscopy and flow cytometry, preferably in the context of advanced models such as 3D matrix scaffolds and organoids. Knowledge of cancer biology would be desirable, and an up-to-date interest in cancer treatments such as immunotherapy would also be an advantage.
Experience working with primary clinical samples – including tissue and blood samples – would also be an advantage, and a commitment to flexible working patterns around sample availability is essential. Knowledge of working within the Human Tissue Act and evidence of good record-keeping are also key skills, as is experience working within inter-disciplinary teams in order to support the clinic-model pipeline.
We welcome applications for flexible working arrangements.
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