CLOSED – Funded PhD: The role of adipose-derived extracellular vesicles and small RNAs in mediating the obesity associated decline in musculoskeletal health with ageing

University of Birmingham

Application closed

We are seeking an applicant for a fully-funded HORIZON-MSCA-2023-DN PhD studentship in the Institute of Inflammation and Ageing at the University of Birmingham, in the group of Prof Simon Jones l to support a translational research project aiming to elucidate the role of extracellular vesicles in obesity-related musculoskeletal decline and frailty. Using advanced nanoparticle tracking microscopy and in vitro human models of the joint and musculoskeletal systems (chondrocytes, osteoblasts, myoblasts), vesicles released from adipose tissue will be characterised, their biodistribution tracked and their functional roles determined. The project will advance understanding of how obesity drives frailty in older adults. As part of the UNION doctoral network, we are expecting the technician to register for a PhD position in the Jones lab at UoB starting in September 2025. As part of the UNION doctoral network, we are expecting the technician to register for a PhD position in the Jones lab at UoB starting in September 2025.

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