University of Loughborough
Application closed
Extracellular vesicles (EVs) are cell-derived nanoparticles that drive a broad range of developmental and regenerative events throughout the body. Within the field of regenerative medicine, mesenchymal stem cells (MSCs) are now being used for the production of therapeutic EVs.
This PhD project builds on aligned industry and EPSRC funded projects within the research group of Dr Owen Davies (OD) that seek to develop EV therapies for a variety of therapeutic applications (e.g. wound healing and regenerative orthopaedics).
In this project, the successful candidate will apply bioreactors to scale up EV manufacture and identify solutions to permit off the shelf applications (e.g. freeze-drying). You will identify critical quality attributes relevant to EV therapeutics and monitor these during the manufacturing process. These developments will be critical in ensuring real world impact is achieved so that promising regenerative therapies have the best chance of progressing from bench to bedside.