If you have any positions, and you’re a member, contact us by email (email@example.com) to advertise them below:
Postdoctoral Research Assistant in Cardiovascular Medicine : RDM Cardiovascular Medicine, University of Oxford, Oxford
Salary: Grade 7: £31,604 p.a.
The Department is pleased to offer an exceptional opportunity for a talented and ambitious postdoctoral scientist to work in a team investigating regenerative medicine strategies after myocardial infarction. You will work under the guidance of Professor Robin Choudhury and Professor Paul Riley to make fundamental discoveries that provide new insights into cardiovascular stem cell function and potency. The current proposal targets the role of the innate immune response using state of the art cellular characterisation and systematic intervention.
You will be expected to manage your own academic research and administrative activities which involves project management and the ability to co-ordinate multiple aspects of work to meet deadlines. As well as this you will test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will hold a PhD/DPhil or equivalent qualification in a relevant discipline as well as a 1st class or upper second class degree. Proven experience with molecular techniques relevant to this project is required and previous experience in histology or Immunohistochemistry is desirable.
This full-time appointment is on a fixed-term contract for 3 years and is funded by the BHF centre of Regenerative Medicine. You will be based on the level 6 West Wing in the John Radcliffe hospital and the Department of Physiology, Anatomy and Genetics (DPAG). Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.
Only applications received before 12.00 midday on 5 April 2018 can be considered. Interviews are scheduled to place mid-April.
The role of exosomes in alpha particles (α-particles) radiation-induced genomic instability & potential lung Cancer induction
Oxford Brookes University – 3 year Full Time PhD project
Research title – The role of exosomes in alpha particles (α-particles) radiation-induced genomic instability & potential lung Cancer induction
Director of Studies and main supervisor: Professor Munira Kadhim
Eligibility: Home UK/EU applicants only —- (who must be permanently resident in UK/EU)
Start Date: September 2018
Value p.a.: Bursary of £14777 for Academic Year 2018/19 & fees
Description of project::
High linear energy transfer (LET) alpha-particles from naturally occurring radon gas dominate human radiation exposure and are the leading cause of lung cancer in humans after smoking. Alpha-particles induce genomic instability (resulting in increased mutation rate) and bystander effects (radiation-like effects induced in unexposed cells) that contribute to cancer development. Recent research in our lab has shown that exposure of cells/tissues to x-rays induces signal transfer through extracellular vesicles (EVs), including exosomes. However, alpha-particles, whose energy deposition pattern and resulting biological effects differ markedly from x-rays, have not yet been studied. This project aims to: investigate exosomes released by lung epithelial cells before and after exposure to different doses and dose rates of alpha-particles, identify molecular signals encapsulated by exosomes, and model the effects induced in un-irradiated lung cells exposed to them.Techniques will include: exosome isolation/purification, analysis of exosome cargo, and functional analysis, including assessment of DNA damage/apoptosis, immune activation, cell cycle/cell population effects and cell motility. The project will establish whether exosomal cargo carries prognostic/diagnostic potential. It will facilitate a search for biomarkers of exposure to alpha particles for possible use in a test to identify those individuals at highest risk for lung cancer caused by radon exposure.
For further details on the research project only please contact main supervisor, Professor Munira Kadhim, firstname.lastname@example.org. Applicants should be of the highest quality and capable of submitting a PhD thesis within 3 years. Applicants should have a first class or upper second class (minimum 2.1) honours degree from a Higher Education Institution in the UK or an acceptable equivalent qualification.
How to apply: With application enclose a CV and scanned copy of your degree certificates and transcripts. Please also provide up to date details of two referees on the application form. Research Administrator would request references from these referees at a later stage. Additionally if appropriate, an IELTS Academic test certificate from an approved test centre. Exceptionally we are prepared to consider alternative acceptable evidence of English Language ability.
With application enclose a CV and scanned copy of your degree certificates and transcripts plus two signed academic references. Additionally if appropriate an IELTS Academic test certificate from an approved test centre. Applications only accepted by e-mail email@example.com